Serotypes of respiratory tract isolates of Streptococcus pneumoniae from Jamaican children

Upton D. Allen, Sonia Thomas, Jonathan Carapetis, Sonia Henry, Samia Wasfy, Marguerite Lovgren, Susan Richardson, Donald E. Low
2003 International Journal of Infectious Diseases  
Data are lacking on the pneumococcal serotypes present in many developing regions, including the Caribbean. We examined the serotypes of nasopharyngeal (NP) isolates of pneumococci obtained from Jamaican children. Methods: We obtained NP samples from children seen in the Emergency Department at the Bustamante Children's Hospital. The samples were transported to Canada for isolation and serotyping of pneumococci. Results: We obtained 94 isolates from 276 children; median age 3.4 years.The
more » ... .4 years.The majority (57%) had symptoms of acute respiratory infection at the time of sampling. The main serotypes carried were 6B (20.5%), 19F (14.5%), and 14 (8.4%). Non-typable isolates accounted for 10.8% of the isolates. Fifty-nine per cent of the serotypes were present among the 11 being considered for candidate pneumococcal conjugate vaccines (95% CI 48-70%); the corresponding proportion present in the recently licensed 7-valent vaccine was 57% (95% CI 45-67%).A significant proportion of the serotypes found is absent from those to be included in future conjugate vaccines (P<O.OOOl; reference=85% expected serotype representation). Less than 5% of isolates were non-susceptible to penicillin (3.2%), cefotaxime-ceftriaxone (3.2%) and cefuroxime (3.2%), while 8.4% and 1.1% of isolates were resistant to trimethoprim-sulfamethoxazole and erythromycin respectively. There were three isolates with resistance to two or more classes of drug. These isolates were all resistant to penicillin (MIC 2 ,ug/mL); the serotypes were 14,23F, and 19F. Conclusion: A significant proportion of the serotypes found is absent from those to be included in future conjugate vaccines. Int J Infect Dis 2003; 7: 29-34
doi:10.1016/s1201-9712(03)90039-7 pmid:12718807 fatcat:nrfdrfqwsbhxdiuye744xkrtge