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The Central Region of Testican-2 Forms a Compact Core and Promotes Cell Migration
2020
International Journal of Molecular Sciences
Testicans are modular proteoglycans of the extracellular matrix of various tissues where they contribute to matrix integrity and exert cellular effects like neurite outgrowth and cell migration. Using testican-2 as a representative member of the family, we tackle the complete lack of general structural information and structure–function relationship. First, we show using isothermal titration calorimetry and modeling that extracellular calcium-binding domain (EC) has only one active
doi:10.3390/ijms21249413
pmid:33321927
fatcat:olzfynxgfjegpldfxyfyv6siju