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This paper details a distributed-memory implementation of Chrysalis, part of the popular Trinity workflow used for de novo transcriptome assembly. We have implemented changes to Chrysalis, which was previously multi-threaded for sharedmemory architectures, to change it to a hybrid implementation which uses both MPI and OpenMP. With the new hybrid implementation, we report speedups of about a factor of twenty for both GraphFromFasta and ReadsToTranscripts on an iDataPlex cluster for a sugarbeetdoi:10.1109/ipdpsw.2014.67 dblp:conf/ipps/SachdevaKJW14 fatcat:zntr64pnk5d73pxx7kxdhf4ojq