Aberrant P53 Expression and the Development of Gallbladder Carcinoma and Adenoma

Shen-Nien Wang, Shin-Chang Chung, Kun-Bow Tsai, Chee-Yin Chai, Wen-Tsun Chang, Kung-Kai Kuo, Jong-Shyone Chen, King-Teh Lee
2006 Kaohsiung Journal of Medical Sciences  
Gallbladder carcinoma (GBC) is a highly lethal but relatively rare neoplasm of the digestive tract. Generally speaking, the overall 5-year survival rate is only 5-15% [1, 2] . GBC also shows an unusual geographic and demographic distribution. It affects females two to six times more frequently than males, and its incidence increases with age [3]. The highest incidences are observed in North and South America, Poland, and northern India. Low incidences are seen in Singapore and Nigeria [4] . In
more » ... aiwan, GBC is also uncommon, and 19.2% of cases are associated with a good operative prognosis [5, 6] .
doi:10.1016/s1607-551x(09)70221-9 pmid:16568721 fatcat:6myt2svn5zhofmrelvfqb7fhgu