Subcutaneous Implantation of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Poly(ε-caprolactone) Scaffolds Modified with Growth Factors
Sovremennye tehnologii v medicine
The aim of the investigation was to assess the tissue response to subcutaneous implantation of nonwoven scaffolds fabricated from biodegradable polymers and further modified by growth factors. Materials and Methods. Specimens were produced by two-phase electrospinning from poly(ε-caprolactone) and a blend of poly(3hydroxybutyrate-co-3-hydroxyvalerate) and poly(ε-caprolactone) both unmodified (controls) and modified with growth factors VEGF, bFGF, and SDF-1α. The ratio of a polymer solution in
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