Paliasa (Kleinhoivia hospita L.) is a plant of the Sterculiaceae family which is known to have potential as an antioxidant. This study aims to determine the total flavonoid content of ethanol extract and various fractions of paliasa leaves on their potential as antioxidants. Samples were macerated with 70% ethanol for 24 hours at room temperature. The ethanol extract obtained was then evaporated at 50 o C to produce a viscous extract which was then fractionated using n -hexane, dichloromethane

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... nd water as solvents. The content of chemical compounds from the ethanol extract of paliasa leaves are alkaloids, flavonoids, saponins, phenols and tannins. The content of chemical compounds from the n -hexane fraction is tannins. The content of chemical compounds from the dichloromethane fraction are flavonoids, phenols and tannins. The content of chemical compounds from the water fraction are alkaloids, saponins, phenols and tannins. Tests for total flavonoid compounds found in the ethanol extract and dichloromethane fraction using rutin as a comparison at λ max 419 nm were 3.10% and 3.73%. Antioxidant activity testing using the 1,1-Diphenyl-2-Picrilhydrazil (DPPH ) method showed that the ethanol extract and fraction ( n -hexane, dichloromethane and water) had an IC of 50 166.55 µg/mL, 351.19 µg/mL, 85 .87 µg/mL, and 226.52 µg/mL, while gallic acid comparator has a very strong antioxidant activity with an IC50 value of 10.75 µg/mL