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Transcriptional Control of Brain Tumour Stem Cell Fate by a Carbohydrate Binding Protein
Brain tumour stem cells (BTSC) and intratumoural heterogeneity represent major challenges for the effective treatment of glioblastoma. EGFRvIII is a key oncogenic protein in glioblastoma, however, the mechanisms that regulate BTSC fate in EGFRvIII subtype of tumours remain poorly characterized. Here, we report our discovery of the lectin, galactoside-binding, soluble 1 (LGALS1) gene, encoding the carbohydrate binding protein, galectin1, as a key regulator of BTSC fate in glioblastoma tumoursdoi:10.1101/2021.04.14.439704 fatcat:st6ju2htxzacxj5ahw653gdhqy