Molecular Epidemiology of Rabies Virus Circulating in South Korea, 1998-2010

Dong-Kun YANG, Eun Kyung SHIN, Yoon-I OH, Hee-Kyung KANG, Kyung-Woo LEE, Soo-Dong CHO, Jae-Young SONG
2011 Journal of Veterinary Medical Science  
We analyzed the nucleotide sequences of the G-L (glycoprotein-large protein) intergenic non-coding region of 33 strains of the rabies virus (RABV) isolated in South Korea in 1998-2010 and compared the sequences with those of previously reported non-Korean strains. The similarities of the nucleotide sequences of the G-L region among all Korean RABV isolates ranged from 97.1 to 100%. Based on the phylogenetic analysis of the G-L region, the Korean RABV isolates were classified into three distinct
more » ... into three distinct subgroups with high similarity and were most closely related to the non-Korean NeiMeng1025C isolate, which was isolated from a rabid raccoon dog in eastern China, suggesting that the Korean RABV isolates originate from a rabid raccoon dog in northeastern Asia. Our results indicated that G-L region, as a useful phylogenetic indicator, is equivalent to the nucleoprotein (N) or glycoprotein (G) gene for study of RABV molecular epidemiology and that the Korean RABV isolates showing a few substitutions in the G-L region are continuously circulating in South Korea.
doi:10.1292/jvms.10-0440 pmid:21467756 fatcat:mknuxs2kuzhcndqvyucm3wpvle