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Int J Clin Exp Pathol
Aberrant DNA methylation plays a significant role in the pathogenesis of chronic myeloid leukemia (CML). CTNNA1 has been found to be low-expressed in some hematologic malignancies and various solid cancers. In the current study, we analyzed the methylation status of CTNNA1 promoter in 70 Chinese patients with CML using methylation-specific PCR (MSP) and examined CTNNA1 expression in 36 patients using real-time quantitative PCR (RQ-PCR). CTNNA1 promoter hypermethylation was present in 21 (30.0%)fatcat:zytpsf6qdrcgtpcdo5glg74zie