PRS Global Open • 2018 surgery, respectively (p<0.05). Adolescents treated with WVC compared to controls, demonstrated an increased connectivity in the salience network in the left insula (MNI: -37,6,-6) and decreased connectivity in the RFPN network in the right BA7 (MNI: 32,-44,55), right sensory association cortex (MNI: 24,-44,51), and right primary sensory cortex (MNI: 24,-41,44) relative to adolescent controls. CONCLUSION: Patients born with sagittal craniosynostosis have abnormal

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... ns in infancy in most of the neural networks compared to controls. There are specific connectivity changes that occur in the RFPN, LFPN, V2, and V3 networks, areas associated with executive function and emotional control, three months after surgery. Changes in anisotropy, measure of white matter tract microstructure, correlate with changes in functional connectivity of areas of the brain connected by white matter tracts after surgery relative to before. Surgery may produce positive changes in the brain microstructure, which could be leading to changes in neural connectivity in the brains of children born with craniosynostosis. As the child develops into adolescence, much of the abnormal network connections seen in infancy correct compared to age-matched controls. However some aberrancies remain in the SA and RFPN network and these residual irregularities may be best handled by other medical therapies.