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Clinical presentation of autoimmune hepatitis can be either acute or chronic or totally asymptomatic. The aim of this study was to assess the impact of asymptomatic onset on AIH natural history. Ninety asymptomatic patients were retrospectively compared to 215 with symptoms. Asymptomatic presentation was characterized by lower histological grading and lower mean levels of aminotransferases, bilirubin, gamma-globulins, IgG and anti-dsDNA. On the other hand, asymptomatic patients were more oftendoi:10.21767/2471-8513.100020 fatcat:u3otyxgjhzd2nnriljf4654e4i