Recommended Patient-Reported Core Set of Symptoms to Measure in Head and Neck Cancer Treatment Trials

Patrick Gavin, Bhishamjit S. Chera, Bryce B. Reeve, Deborah Watkins Bruner, Barbara A. Murphy, John A. Ridge, Avraham Eisbruch, Benjamin Movsas
We identified a standard core set of patient-reported symptoms and health-related quality-of-life (HRQOL) domains to be assessed in head and neck (H&N) cancer clinical trials. The core symptom and HRQOL domain scores were used to guide recommendations by a working group of experts as part of a National Cancer Institute Symptom Management and HRQOL Clinical Trials Planning Meeting. A PubMed search was conducted using the search terms of "health-related quality of life" and "head & neck cancer,"
more » ... imited to publications from January 1, 2000, to December 31, 2010. Fifty-four articles were used to guide the choice of recommendations. Twenty-nine symptoms and nine domains were identified, from which 12 H&N-specific core symptoms and HRQOL domains were recommended: swallowing, oral pain, skin changes, dry mouth, dental health, opening mouth/trismus, taste, excess/thick mucous/saliva, shoulder disability/motion, voice/hoarseness, social domain, and functional domain. This core set of 12 H&N-specific, patient-reported symptoms and HRQOL domains should be assessed in future H&N cancer clinical trials.
doi:10.17615/ghz1-wj16 fatcat:4ruiei4qzjcfplppfgppcqrbtu