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CTCF, Cohesin, and Chromatin in Human Cancer
2017
Genomics & Informatics
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range
doi:10.5808/gi.2017.15.4.114
pmid:29307136
pmcid:PMC5769866
fatcat:iq3xejrubjgpxkuajssgvjqkg4