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Purpose: The interaction of various substances inserted into the human body and radiation can confirm the radiation enhancement effect. A Leksell frame inserted into the human body for gamma knife treatment will cause not only pain and inconvenience to the patient, but also additional exposure to the patient's normal tissues. In this study, we attempt to confirm the additional exposure caused by the interaction of the Leksell frame and thermoplastic mask, and 60 Co used for gamma knifedoi:10.14316/pmp.2020.31.2.29 fatcat:adakkrlggrblhianztvt546eta