Profile of acute lymphoblastic leukemia in children upto 2 years of age – Study from a Tertiary Cancer Centre from South India, Bangalore

C. Anoop, L. Appaji, M. Padma, B.S. Arunakumari, M. Avinash, T.L. Suma, Madhumati, V.K. Rekha
2016 Pediatric Hematology Oncology Journal  
chemotherapy for ALL according to the Modified BFM ALL 95 protocol at our institute, from January 1st 2015 to December 31st 2015. Hyperglycemia was diagnosed with a random blood sugar (RBS) level of 200mg/dl or a fasting blood sugar (FBS) value of 126mg/dl. Patients with pre-existing diabetes were excluded from analysis. Results: 165 children with newly diagnosed ALL were analysed of which eight patients (4.8%) were detected to have hyperglycemia (Range 139 e 646mg/dl). Seven of the patients
more » ... e females and 50% of them were 10 years of age. No patient had pre-existing diabetes. Five patients (62.5%) required insulin along with metformin to attain adequate glucose control while two patients were treated with metformin alone. One of the patients developed hyperglycemia with an RBS of 264 while on treatment for septic shock and expired shortly after. One child presented with ketoacidosis associated with blood sugar of 554mg/dl and also had pancreatitis. Two children had a family history of diabetes mellitus. Conclusion: The occurrence of hyperglycemia in our study was lower than previously reported in literature. The incidence of hyperglycemia was significantly increased in female children 10 years of age (p¼0.002).
doi:10.1016/j.phoj.2016.10.021 fatcat:2qpkyfuhgvgmffgwcwql5xboce