Imbalance of Testosterone Level in Male Offspring of Rats Perinatally Exposed to Bisphenol A

Sumiko WATANABE, Rui-Sheng WANG, Muneyuki MIYAGAWA, Kenichi KOBAYASHI, Megumi SUDA, Soichiro SEKIGUCHI, Takeshi HONMA
2003 Industrial Health  
The purpose of this study was to investigate whether exposure to bisphenol A (BPA) through the placenta and milk has any effect on the reproductive system in male offspring. Pregnant rats were treated with BPA at 0, 4, 40 and 400 mg/kg body weight, from gestation day 6 through lactation day 20 by gavage. Plasma testosterone concentrations in offspring at 9 weeks old were significantly high in BPA groups as compared with those of the control. At the age of 36 weeks the hormone concentrations
more » ... ed an increase in a dose-dependent manner, although without statistical significance. Testosterone content in testes showed a similar tendency to that in plasma, though statistically insignificant. Little alteration in testes weight was seen in BPA-exposed offspring. There was no remarkable change in plasma concentrations of luteinizing hormone and follicle-stimulating hormone at 9 weeks old. The pathway of E 2 (17β β β β β-estradiol) formation from testosterone seemed not to be affected by BPA. The results indicate that exposure to BPA during the perinatal period has a significant effect on testosterone homeostasis in male offspring of rats.
doi:10.2486/indhealth.41.338 pmid:14620671 fatcat:53qyou3qofbmbf5ta67ujklmqe