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Journal of Virology
Human papillomaviruses (HPVs) have been implicated in the development of a number of human malignancies, but direct tests of their involvement have not been possible. We describe a system in which human skin from various sites was infected with HPV type 11 (HPV-l1) extracted from vulvar condylomata and was grafted beneath the renal capsule of athymic mice. Most of the skin grafts so treated underwent morphological transformation, resulting in the development of condylomata identical to thosedoi:10.1128/jvi.59.2.369-376.1986 fatcat:m5hopy3sb5gdfpxp3semqkvfi4