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Engineering a Circular Riboregulator in Escherichia coli
2020
BioDesign Research
RNAs of different shapes and sizes, natural or synthetic, can regulate gene expression in prokaryotes and eukaryotes. Circular RNAs have recently appeared to be more widespread than previously thought, but their role in prokaryotes remains elusive. Here, by inserting a riboregulatory sequence within a group I permuted intron-exon ribozyme, we created a small noncoding RNA that self-splices to produce a circular riboregulator in Escherichia coli. We showed that the resulting riboregulator can
doi:10.34133/2020/1916789
pmid:37849901
pmcid:PMC10521646
fatcat:ytk6ytroqbazzg5nmehs4duidu