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The immune response of mice to armadillo-derived, irradiation-killed Mycobacterium leprae (I-ML) was investigated. Following injection of 100 jig of I-ML into the left hind footpads of mice, a state of cell-mediated immunity (CMI) was engendered to antigens of M. leprae. The evidence for CMI was as follows: (i) development of delayed-type hypersensitivity to both human tuberculin purified protein derivative and soluble M. leprae antigens; (ii) T-lymphocyte-dependent macrophage activation at thedoi:10.1128/iai.19.1.87-93.1978 fatcat:nin4ov5nbfcsll66fb43v5ts3m