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PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating IKs and ICaL—insights from human atrial modelling
2020
Annals of Translational Medicine
Functional analysis has shown that the paired-like homeodomain transcription factor 2 (PITX2) overexpression associated with atrial fibrillation (AF) leads to the slow delayed rectifier K+ current (IKs ) increase and the L-type Ca2+ current (ICaL ) reduction observed in isolated right atrial myocytes from chronic AF (CAF) patients. Through multiscale computational models, this study aimed to investigate the functional impact of the PITX2 overexpression on atrial electrical activity. The
doi:10.21037/atm.2020.01.90
pmid:32309338
pmcid:PMC7154416
fatcat:72glxpamn5gkpg7htlpwkmz55i