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The time-course of the fluxes causing net sodium uptake through the anal papillae, and the control of this uptake, have been studied in fed sodium-deficient fourth-instar larvae of the mosquito Aëdes aegypti in 2 mM/1 NaCl. Influx, outflux and uptake rate all decline exponentially with time, suggesting that effective negative feedback operates continually upon the transporting system. Uptake is impaired or eventually stopped when certain tissues are destroyed, or ligatured or clamped out of thedoi:10.1242/jeb.54.1.29 fatcat:vtnqndwfovfepj47snfgvfs3rm