Objective: To investigate the inhibitory effects of zoledronic acid (ZA) on tumor related growth factor IL-6 in hormone resistant prostate cancer cell lines. The association between apoptosis and IL-6 inhibition was also assessed. Materials and Methods: PC-3 and DU145 cell lines were treated with different concentrations of ZA (1-100μM) at various intervals (24-72 h.). The cell viability was investigated by XTT assay and apoptotic effect was evaluated by cell death Results: PC-3 and DU145 cell

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... ines were sensitive to ZA mediated cytotoxicity in a dose-and time-dependent manner. of IL-6 secretion was associated with increased apoptosis in DU145 cells (p = 0.002), there was no similar association for Conclusion: ZA exhibited a time-and dose-dependent apoptotic effect on PC-3 and DU145 prostate cancer cell lines and this effect was associated with inhibited secretion of IL-6 in DU145 cell line.