Diarrhoea is a major public health problem especially in developing countries. The signs and symptoms of Diarrhoea can nearly be co-related to Atisara. Diarrhoea caused by bacterial pathogens can be equated with the lakshanas seen in Krimija Atisara. Hetu vyadhi pratyanika chikitsa is explained by Acharya Sushruta for treating Krimija Atisara. In Yogamritam Atisara chikitsa Adhikara; it is explained that Chakramarda patra Swarasa, taken along with Dadhi is effective in Atisara. Hence, the study

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... has been undertaken as a pre-clinical step- In vitro Agar well diffusion model, Microorganisms used for the study are E coli and Staphylococcus aureus. Two trial groups were included in this study; trial group 1- Chakramarda patra Swarasa alone, Trial group 2- Chakramarda patra Swarasa with Dadhi. Gentamicin was used as Standard. It was observed that the 2 trial groups showed Zone of inhibition against E coli and Staphylococcus aureus. Both the trial groups showed More Zone of inhibition against Staphylococcus aureus than E coli. Mean zone of inhibition of the 2 trial groups was found to be lower as compared to that of Mean zone of inhibition of the standard against E coli and Staphylococcus aureus. Student 't' test is used to analyze the data. The 't' value is not statistically significant at the level of P < 0.05. Hence null hypothesis is accepted and alternate hypothesis is rejected.This article aims to give a scientific validity to usage of Chakramarda patra Swarasa with Dadhi in Krimija Atisara.