Article aimed at analyzing the biojuridical limits appropriate to the use of gene editing as a therapeutic protocol, without this practice violating the necessary preservation of the integrity of the human and environmental genetic heritage. From this perspective, we sought to assess the challenges in guaranteeing genetic integrity and diversity. The methodological path followed was the analytic-discursive, identifying fundamental connections related to the problem and interpreting the

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... l and biojuridical concepts in favor of the conclusion regarding the proposed problem. This is a bibliographic review, based on books, chapters in collective works and articles published in leading journals in the area. The use of new therapeutic options such as gene editing emerges in the current scenario as a tool of unknown proportions. Its means must always be used with clear ethical and legal limits to avoid the degradation of the genetic heritage. Add reflections about the new biotechnological paradigms in the era of the new genetics and the necessary legislative update so that there is a better protective standard.