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Mounting evidence implicates the zebrafi sh ( Danio rerio ) as a promising model species for reward and addiction research. Modeling drug abuse-related behavior in both adult and larval zebrafi sh produced a wealth of clinically translatable data, also demonstrating their sensitivity to various drugs of abuse and the ability to develop tolerance. Several studies have also applied withdrawal paradigms to model the adverse effects of drug abuse in zebrafi sh. In this review, we summarize recentdoi:10.1515/rns.2011.011 pmid:21615264 fatcat:j2dqwro3i5bovm6rtyozlhczye