Neuroprotective action of 4-hydroxyisophthalic acid against ethanol-induced oxidative stress in the rat brain

Dileep Kumar H. V., Shivanandappa T.
2019 Asian Journal of Pharmacy and Pharmacology  
Objective: 4-Hydroxyisophthalic acid (4-HIPA) is a novel bioactive molecule isolated in our laboratory from the edible roots of . Earlier we have shown free radical scavenging activity of 4-HIPA and Decalepis hamiltonii in vitro cytoprotective action. Here we report neuroprotective potential of 4-HIPA against ethanol-induced oxidative in vivo stress in the brain of laboratory rat. Rats were treated with ethanol (5g/kg bw) in single and Materials and Methods: multiple doses with/without
more » ... ment with 4-HIPA (200mg/kg bw). Ethanol induced oxidative stress in Results: both single and multiple dose treatment showed regional differences. Oxidative stress in the cerebral cortex and cerebellum being higher in the latter as indicated by the increased reactive oxygen species, lipid peroxidation, protein carbonyls and glutathione depletion. Pre-treatment with 4-HIPA significantly restored the alterations induced by ethanol. 4-HIPA protected against ethanol-induced oxidative stress by boosting the antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase. 4-HIPA Conclusion: is a potential neuroprotective molecule of natural origin and shows the promise natural bioactive compound derived from edible source against alcohol toxicity. Therefore, 4-HIPA has health implications as a nutraceutical against alcohol abuse.
doi:10.31024/ajpp.2019.5.4.27 fatcat:eetgoxzv5zfjrmy2cybvia4haq