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Smad3 Deficiency Counteracts Hepatocyte Apoptosis and Portal Fibrogenesis Induced By Bile Duct Ligation
2014
Journal of Liver
Objectives: Transforming Growth Factor (TGF)-β is reportedly upregulated and plays a critical role in hepatic fibrogenesis. We aim to study the role of the Smad3, a key transcription factor downstream of TGF-β receptors, signaling pathway in the pathogenesis of cholestatic liver injury induced by Bile Duct Ligation (BDL). Materials and methods: We used mice lacking Smad3 (Smad3 ex8/ex8 ), and their wild-type littermates to model hepatic fibrosis using BDL. The underlying biology was
doi:10.4172/2167-0889.1000145
fatcat:5hrzs5htwjftpakbz2r2nr3c4m