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We consider the problem of anatomy based dose optimization in brachytherapy. A calculation method for some o bjective functions and their derivatives is proposed which significantly reduces the number of required operations. The optimization in some cases, ignoring a preprocessing step, is independent of the number of sampling points. The idea is that some of the objectives and their derivatives used for dose optimization do not require the explicit calculation of dose values. Dose optimizationdoi:10.1118/1.1580483 pmid:14528959 fatcat:yqcqmtcdnrhe7i6lagrbtjrcnm