Hypolipidemic effect of methoxyflavone-enriched extract of Kaempferia parviflora in cholesterol-induced dyslipidemic rats Hypolipidemic effect of methoxyflavone-enriched extract of Kaempferia parviflora 2 in cholesterol-induced dyslipidemic rats

Somsuda Somintara, Bungorn Sripanidkulchai, Choowadee Pariwatthanakun, Kittisak Sripanidkulchai
R1 Sripanidkulchai Songklanakarin Journal of Science and Technology   unpublished
14 Kaempferia parviflora is a Zingiberaceae plant that has been used as traditional 15 medicine in Asia. The pharmacological effects have been widely reported such as anti-16 inflammatory, anti-allergy, anti-obesity and suppression of adipocyte hypertrophy. This 17 study aimed to examine the hypolipidemic effect of methoxyflavone-enriched extract of 18 K. parviflora rhizome (MKE) in cholesterol-induced dyslipidemic rats. To develop the 19 hypercholesteroremic condition, the rats were fed with
more » ... olesterol (2g/kg) twice a day 20 for 6 weeks. Dyslipidemic rats were divided into 6 groups including three control 21 vehicle groups, two doses of MKE treatment groups, and a simvastatin positive control 22 group. Oral administration of MKE at daily doses of 150 or 300 mg/kg for 12 weeks 23 significantly decreased in the levels of cholesterol, triglyceride and LDL. The MKE and 24 1 suggest that MKE and its active components exhibit hypolipidemic effects in 2 dyslipidemic rats. 134 words 3 4