There has been an increasing focus on development of new routes of drug administration to provide tailored treatments for patients, without decreasing efficacy of analgesia, in proportion to the progression of the knowledge of pain mechanisms. While acute pain acts as an alarm, chronic pain is a syndrome requiring meticulous selection of analgesic drugs of high bioavailability for long-term use. Such criteria are challenges that topical medications aim to overcome, allowing progressive delivery

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... of active component, maintaining stable plasma levels, with a good safety profile. This review presents recent findings regarding topical formulations of the most widely used drugs for pain treatment, ; Disclosed herein is a herbal balm composition and the method of preparing said composition. The composition comprising extracts of organically certified herbs, organic essential oils and organic beeswax, wherein the extract is prepared employing a super critical fluid extraction (SCFE) and where in the essential oils used herein is obtained by cold pressed method. The oils used in it is used as a pain killer. Key words; natural pain relief balm, vitex negundo oil, Eucalyptus oil