The arginine and GHRP-2 tests as alternatives to the insulin tolerance test for the diagnosis of adult GH deficiency in Japanese patients: A comparison

Yasuyuki Kinoshita, Atsushi Tominaga, Satoshi Usui, Kazunori Arita, Tetsuhiko Sakoguchi, Kazuhiko Sugiyama, Kaoru Kurisu
2013 Endocrine journal  
It has been well recognized that adult GH deficiency (AGHD) is associated with a number of metabolic abnormalities and a decline in exercise capacity, and that GH replacement improves these impairments [1], but the treatment of AGHD is very expensive, with a high cost of long-term care and drug therapy. In Japan, hypopituitarism (including AGHD) was designated as a Specified Rare and Intractable Disease from October 2009, and the treatment of AGHD is publicly subsidized. Now, accurate diagnosis
more » ... is required to manage AGHD for individual patients, as well as for
doi:10.1507/endocrj.ej12-0230 pmid:23079545 fatcat:7t4gbmu62fcnhmnk4sih5mfiqi