Oxymatrine attenuates amyloid beta 42 (Aβ1–42)-induced neurotoxicity in primary neuronal cells and memory impairment in rats

Peiliang Dong, Xiaomeng Ji, Wei Han, Hua Han
2019 Canadian Journal of Physiology and Pharmacology  
16 Aβ 1-42 -induced oxidative stress causes the death of neuronal cells, which is involved 17 in the development of Alzheimer's disease (AD). Oxymatrine (OMT) inhibits 18 oxidative stress. In this study, we investigated the effect of OMT on Aβ 1-42 -induced 19 neurotoxicity in vivo and in vitro. In the Morris water maze test, OMT significantly 20 decreased the escape latency and increased the number of platform crossings. In vitro, 21 OMT markedly increased cell viability and superoxide
more » ... e activity. Moreover, 22 OMT decreased the lactate dehydrogenase leakage, malondialdehyde content, and 23 reactive oxygen species in a dose-dependent manner. OMT upregulated the ratio of 24 Bcl-2/Bax and downregulated the level of caspase-3. Furthermore, OMT inhibited the 25 activation of MAPK (ERK 1/2, JNK) and NF-κB. In summary, OMT may be a 26 potential compound for the treatment of AD. 27
doi:10.1139/cjpp-2018-0299 fatcat:zwqz6arkhraqvhlwauhsmudm2u