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16 Aβ 1-42 -induced oxidative stress causes the death of neuronal cells, which is involved 17 in the development of Alzheimer's disease (AD). Oxymatrine (OMT) inhibits 18 oxidative stress. In this study, we investigated the effect of OMT on Aβ 1-42 -induced 19 neurotoxicity in vivo and in vitro. In the Morris water maze test, OMT significantly 20 decreased the escape latency and increased the number of platform crossings. In vitro, 21 OMT markedly increased cell viability and superoxidedoi:10.1139/cjpp-2018-0299 fatcat:zwqz6arkhraqvhlwauhsmudm2u