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Two mathematical models for tumor anti-angiogenesis, one originally formulated by Hahnfeldt et al. in  and a modification of this model by Ergun et al. , are considered as optimal control problem with the aim of maximizing the tumor reduction achievable with an a priori given amount of angiogenic inhibitors. For both models optimal controls contain a segment along which the dosage follows a so-called singular control, a time-varying feedback control. In this paper the efficiency ofdoi:10.1093/imammb/dqp012 pmid:20513667 fatcat:rek46vbqgnaj7igkdlorr236ou