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Protein Inhibitor of Activated STAT-1 (Signal Transducer and Activator of Transcription-1) Is a Nuclear Receptor Coregulator Expressed in Human Testis
An androgen receptor (AR) interacting protein was isolated from a HeLa cell cDNA library by twohybrid screening in yeast using the AR DNA؉ligand binding domains as bait. The protein has sequence identity with human protein inhibitor of activated signal transducer and activator of transcription (PIAS1) and human Gu RNA helicase II binding protein (GBP). Binding of PIAS1 to human AR DNA؉ligand binding domains was androgen dependent in the yeast liquid ␤-galactosidase assay. Activation of bindingdoi:10.1210/mend.14.1.0408 pmid:10628744 fatcat:otkjizt53fc2rgjifpa5po6vku