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Ácidos graxos de cadeia média como ligantes da proteína PPAR
PPARs (peroxisome proliferator activated receptors) are nuclear receptors that regulate glucose and fat metabolism, adipogenesis and macrophage polarization and mediate actions of a major class of drugs that are used to treat type 2 diabetes, the thiazolidinediones. While TZDs reduce blood glucose and improve insulin sensitivity effectively, they can also exhibit deleterious side effects such as increased cardiovascular risk, weight gain, fluid retention and liver toxicity. Because it isdoi:10.11606/d.76.2009.tde-19032009-111236 fatcat:ir773c7ezvf3vkaiplsvuxnd3a