The effective reaction of 2-chloro-3-formylquinoline and acetic acid/sodium acetate under microwave irradiation

V Nadaraj, ST Selvi
2011 International Journal of Engineering, Science and Technology  
Pyrano[2,3-b]quinolin-2-ones have been synthesized efficiently from 2-chloro-3-formylquinolines in a single step by treating with sodium acetate and acetic acid under microwave irradiation. The structures of the compounds have been established by IR, NMR and mass spectral data. Unexpectedly, 3-formylquinolin-2(1H)-ones were exclusively formed in very high yields by changing the molar ratio of acetic acid and sodium acetate in just 1.5 to 2.5 min. major metabolite of the anti-allergic drug
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doi:10.4314/ijest.v3i4.68561 fatcat:fvpcmx3z2fahtk6winhctttw3m