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The registration of intraoperative Ultrasound (US) with preoperative Magnetic Resonance (MR) images is a challenging problem due to the difference of information contained in each image modality. To overcome this difficulty, we introduce a new probabilistic function for similarity measurements based on the mean curvature of MR isophots and US hyperchogenic structures. Experiments were carried out on 3 patients and compared with three other registration approaches. The results show that thedoi:10.1109/isbi.2007.357103 dblp:conf/isbi/CoupeHMB07 fatcat:c3czo5mz7fhkrhwjtsqjhh62km