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The early detection of lymphoma in patients can greatly increase the probability of recovery. Centroblasts of lymphoma are conventionally identified under microscopes by expert doctor's manually. cytogenetics and immunopheno typing are currently used. A novel method has been proposed to recognize centroblast (CB) cells from non centroblast (non-CB) cells for computer assisted evaluation of lymphocyte centroblasts. The novel aspects is to identify the centroblast cells with prior information.doi:10.5120/12474-8869 fatcat:cprfzu3l5zc5nks2obgveg2tye