Influence of lung nodule margin on volume- and diameter-based reader variability in CT lung cancer screening

Daiwei Han, Marjolein Heuvelmans, Rozemarijn Vliegenthart, Mieneke Rook, Monique D Dorrius, Gonda de Jonge, Joan E Walter, Peter M.A. van Ooijen, Harry J. de Koning, Matthijs Oudkerk
2017 British Journal of Radiology  
Interest in lung cancer screening by low-dose CT (LDCT) is increasing, ever since the National Lung Screening Trial (NLST) showed that LDCT screening for individuals at high risk of lung cancer reduces lung cancer mortality by 15-20%, compared with chest radiography. 1 A major drawback faced by the NLST was the high prevalence of false-positive screen results, which was 28.7% in NLST screen participants. 2 This high false-positive rate may result in patient harm and increased healthcare cost.
more » ... provements in nodule management such as a raised size threshold for positive nodules and the use
doi:10.1259/bjr.20170405 pmid:28972803 fatcat:mdook26zd5du3gdnzrnfl6gq3i