Ethanol Suppresses the Effects of Sodium Arsenite in Male Wister Albino Rats

Muhammad Aliyu, Oyeronke A Odunola
2012 Journal of Clinical Toxicology  
Millions of people around the world get exposed to high levels of heavy metals in drinking-water. Therefore, quality control in drinking-water, food industries and detection of heavy metals is an extremely critical issue in maintaining the human health. Of such heavy metals is arsenic. Water as one of the major ingredient in both traditional and modern beer fermentation process may/may not be contaminated with arsenic due to poor quality control. As a result people are exposed to the end
more » ... d to the end product which constituted arsenic compound. Sodium arsenite and ethanol has been established to be toxic both in vivo and in vitro. Objective: This study is primarily designed to investigate the effect of co-administration of sodium arsenite and ethanol in male Wister albino rats. Methods: Forty five (45) albino rats divided into nine (9) groups of five rats each were administered with distilled water, 2.5mg and 5mg/kg body weight of sodium arsenite, 3% and 6% (v/v) respectively. Treatment was based on single and combined administration. Micronucleated polychromatic erythrocytes, acetylcholine esterase, Aspartate Transaminase (AST), Alkaline Phosphatase (ALP), Alanine Transaminase (ALT) and hematological parameters were determined by standard procedures (Figure 1) . Results: Combined treatment with sodium arsenite and ethanol significantly decreased the number of micro nucleated polychromatic erythrocytes, AST, ALT and ALP activities as against the single treated groups. However, there was stabilization of acetylcholine esterase activity in the brain. The hematological parameters level was also stabilized. Conclusions: We therefore proposed that the chemical interaction between sodium arsenite and ethanol is what was responsible for the suppression of sodium arsenite -induced clastogenic, hepatotoxic, anti-acetylcholine esterase and anemic effects. Citation: Aliyu M, Odunola OA, Owumi SE, Habila N, Aimola IA, et al. (2012) Ethanol Suppresses the Effects of Sodium Arsenite in Male Wister Albino Rats. 1: 222.
doi:10.4172/scientificreports.222 fatcat:jlrv7rnh4za7jg47mlji7glnzy