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Oxidative stress induced by cadmium (Cd) is a common phenomenon that has been observed in numerous studies. However, the underlying mechanism remains unknown. Recently, exposure of PC-12 cells to Cd has been shown to activate autophagy, which acts as a temporary survival pathway under stressful conditions by delaying the occurrence of apoptosis. The present study investigated the impact of oxidative stress on Cd-induced autophagy in PC-12 cells. The results demonstrated that Cd-induceddoi:10.3892/mmr.2015.3907 pmid:26062759 fatcat:ydognsfrrfasveuzqlgog5zqfm