Evaluation of Target Definition for Management of Myxoid Liposarcoma (MLS) with Neoadjuvant Radiation Therapy (RT)
Biomedical Journal of Scientific & Technical Research
Objective: Radiation therapy (RT) typically plays a major role in the management of soft tissue sarcomas. In the context of myxoid liposarcoma (MLS) management, several studies have addressed the utility of neoadjuvant RT. Longer life expectancy of patients with MLS with more efficacious treatments rendered quality of life a critical aspect of management. From this standpoint, improving the toxicity profile of radiation delivery has gained utmost priority in the millennium era. Accurate RT
... t definition comprises an indispensable and critical component of successful MLS management. Within this context, we assessed target definition for neoadjuvant RT of MLS in this original article. Materials and Methods: A comparative evaluation was performed regarding target definition with multimodality imaging by incorporation of magnetic resonance imaging (MRI) or by computed tomography (CT)-simulation images only for patients receiving neoadjuvant RT for MLS. Results : Priorities in RT planning included encompassing of target volumes adequately with optimal sparing of critical structures. Determination of ground truth target volume was performed by the board-certified radiation oncologists after meticulous assessment, collaboration, colleague peer review, and ultimate consensus. Target definition by CT-only imaging and by CT-MR fusion based imaging was assessed with comparative analysis. Ground truth target volume was found to be identical with target volume determination by CT-MR fusion based imaging as the primary endpoint result of the study. Conclusion: Multimodality imaging should be considered for target definition of MLS for neoadjuvant radiotherapeutic management. Clearly, further studies are warranted to address this issue.