Effect of 5-azacytidine on phytohemagglutinin-stimulated horse lymphocytes and cultured mouse L929 cells

B S Zain, R L Adams, R C Imrie
1973 Cancer Research  
The effect of 5-azacytidine on the metabolism of phytohemagglutinin-stimulated horse lymphocytes and cultured mouse L929 cells has been investigated. No significant differences have been found between the two cell types. The effects of 5-azacytidine become irreversible after 1 hr of treatment and, at this time, protein synthesis is dramatically inhibited. Subsequently, inhibition of RNA and DNA synthesis occurs.
pmid:4118429 fatcat:5anpyz7z6ffshlj7b7ofeyrt4a