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Renal cell carcinoma (RCC) represents 2-3% of adult malignant tumors and constitutes 90% of the malignant tumors that affect the kidney. RCC metastatic disease (m-RCC) occurs in a significant percentage and is usually associated with an overall poor prognosis. This tumor is hypervascular and that is why tyrosine kinase inhibitors (TKI), that target the intracellular kinase domain of the vascular endothelial growth factor receptor, have become established as the most successful drug in thisdoi:10.19080/ctoij.2018.10.555786 fatcat:6gqp3tjmrfa45dwona5rqy6hsi