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Experiments were carried out on outbred rabbits of both sexes using neurophysiological methods. We resurched the ability of analgesics, antidepressants and their combinations tochange parameters of electrophysiological brain activity under conditions of normal functioning of the central nervous system and on the background ofsimulated depression. Found that in brain pathology combination analgesics with amitriptyline caused activation of the reticular formation (RF) and in-creased excitabilitydoaj:205b9349ff25443385aab10929979ea5 fatcat:dnmzgmfnkbdhvp6d3q6rl2naqa