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Loxosceles is a genus of cosmopolitan spiders comprising several species, and popularly knownas brown spiders or brown recluses. Brown spider bites can cause dermonecrotic lesions andsystemic reactions known as loxoscelism. Systemic effects are less common but may be severe oreven fatal in some patients. Systemic manifestations include intravascular hemolysis, disseminatedintravascular coagulation and acute renal failure. A rapid diagnosis and an understanding of thevenom's molecular activitydoaj:954ecbf79c0c42cba5c804b41f2542d4 fatcat:nhmnzbpyuzginojhsrnzwc5eee