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Roles of mTOR-regulating GTPases in regulating drug resistance in senescence-like hepatoma cells
[post]
2021
unpublished
Radiotherapy and chemotherapy can arrest cancer cells in a senescence-like state, which can lead to therapy resistance and cancer relapse. Despite the cell cycle arrest, senescence-like cells have persistent mTOR activity that is insensitive to nutrient starvation. The mechanisms and functions of mTOR activation in senescence-like cells remains unclear. mTOR is regulated by several small GTPases including the lysosome-localized Rag complex, ER-Golgi-localized Arf1 and Rab1, and
doi:10.21203/rs.3.rs-1014270/v1
fatcat:mkddkmxv3zevrc3qc63xmobhom