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How cells manage biomolecule supply to enable constructive metabolism for growth is a fundamental question. Methionine directly activates genomic programs where translation and metabolism are induced. In otherwise amino acid limitations, methionine induced ribosomal biogenesis, carbon metabolism, amino acid and nucleotide biosynthesis. Here, we find that the methionine-induced anabolic program is carbon-source independent, and requires the starvation-responsive transcription factor Gcn4/ATF4.doi:10.1101/2020.01.29.924274 fatcat:fpzfazppardlnl4j75as45cgta