Treatment of latent tuberculosis (TB) infection (LTBI) is essential for the elimination of TB in the United States, but treatment is often not completed. Little is known about patients' reasons for not completing treatment. We hypothesized that certain health beliefs, lifestyle, and clinic-and regimen-related barriers to provision of care could predict non-completion of LTBI treatment. Methods: We administered a survey in English, Chinese, or Spanish to patients with LTBI at the first TB clinic

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... visit. Using 2 and logistic regression analysis, we assessed demographics, TB risk factors, and survey responses as predictors of non-completion of 6 mo of isoniazid. Results: 217 patients, 90% foreign-born, completed the survey, and 28.6% of which finished at least 6 mo of isoniazid under usual clinic conditions. Multivariate analysis identified two independent predictors of non-completion: low risk perception of progressing to active TB without LTBI treatment (odds ratio [OR], 0.31 [0.13-0.72], 95% confidence interval [CI]), p ϭ 0.007, accounting for 20% of non-completers, and not wanting venipuncture (OR, 0.43 [0.22-0.85], 95% CI), p ϭ 0.015, accounting for 37% of non-completers. Another 18% shared both predictors; thus these two predictors accounted for 75% of non-completers in total. Conclusions: Patients assess LTBI treatment risks and inconveniences relative to low perceived benefits at treatment outset. Predictors of LTBI treatment non-completion are identifiable at the first visit. Targeting TB high-risk individuals, minimizing inconveniences, further education, and use of diagnostic tests with improved specificity for TB may address these concerns. As the incidence of tuberculosis (TB) disease has decreased in the United States, the diagnosis and treatment of latent TB infection (LTBI) has assumed increasing importance. Standard LTBI treatment is daily isoniazid for 6 to, preferably, 9 mo, with completion rates often ranging from 20 to 60% for 6 mo of isoniazid (1, 2). Limited objective information is available regarding factors influencing adherence to LTBI treatment. We hypothesized that barriers to the provision of TB care, related to regimen or clinic, or in beliefs regarding tuberculosis or health and lifestyle in general, could be identified at the outset of treatment. We have presented preliminary findings from this study previously in the form of an abstract (3).