IL-17E, a Novel Proinflammatory Ligand for the IL-17 Receptor Homolog IL-17Rh1

James Lee, Wei-Hsien Ho, Miko Maruoka, Racquel T. Corpuz, Daryl T. Baldwin, Jessica S. Foster, Audrey D. Goddard, Daniel G. Yansura, Richard L. Vandlen, William I. Wood, Austin L. Gurney
2000 Journal of Biological Chemistry  
We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in
more » ... ple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-B and stimulates production of the proinflammatory chemokine IL-8.
doi:10.1074/jbc.m008289200 pmid:11058597 fatcat:rrel746z5re37ctuacsja6evri